Alay Jain, M.D., Assistant Professor of Pediatrics and Medical Director of the Pediatric Liver Transplant program at Cardinal Glennon Children’s Hospital, received a grant from the National Institute of Diabetes and Digestive and Kidney Diseases at the NIH to continue studies on the adverse effects of parenteral nutrition (PN) or intravenous feeding.

PN is needed in patients when part or all of their digestive systems are not working properly due to injury or disease. Despite being life-saving treatment, it can cause severe side effects, such as liver and bowel disorders, that can be fatal. Dr. Jain’s research focuses on bile acid pathways, which are interrupted when nutrition is only given intravenously. In a clinical setting, he has found that these adverse side effects can be alleviated when some feeding is done via the gut, in order to maintain the normal gut and liver communication pathways.

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