Daniela Salvemini, Ph.D., Professor of Pharmacology and Physiology, published a paper in Pain detailing studies on treating metastatic bone pain, the most common form of pain in cancer patients.
Dr. Salvemini recently discovered molecular pathways that lead to pain and found that sphingosine 1-phosphate receptor subtype 1, or S1PR1, is key in the molecular cascade. Increases in S1PR1 lead to increased pain. The researchers found that blocking S1PR1 in an animal model of breast cancer metastatized to the femur resulted in blocking pain signals.
For more information, read the full article in Newslink.