Duane Grandgenett, Ph.D., Professor of the Institute for Molecular Virology, along with colleagues from the University of Minnesota and Cornell University, recently published a paper in Nature reporting the crystal structure of the Rous sarcoma virus (RSV) intasome.

The intasome is involved in integration of the virus into the host genome via integrase and is an essential step in the viral life cycle. The structure of the RSV instasome is very similar to that of HIV, which could aid in understanding integration of HIV and other retroviruses. Dr. Grandgenett discovered integrase in 1978 and this enzyme is now the basis for the safe and effective class of drugs used to treat HIV infection.

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